Recent Patents on Anti-Infective Drug Discovery

Dieter Kabelitz  
Institute of Immunology
Universitätsklinikum Schleswig-Holstein
Campus Kiel
Arnold-Heller-Straße 3
Kiel, D-24105
Germany

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Treatment of Tuberculosis: Use of Active Pharmaceuticals

Author(s): Abdus Samad, Yasmin Sultana, Md. S. Akhter and Mohammad Aqil

Affiliation: Department of Pharmaceutics,Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110 062, India.

Keywords: Mycobacterium, tuberculosis, antimycobacterial agents, natural products, synthetic and semi-synthetic products

Abstract:

Tuberculosis (TB) is a highly infectious disease caused by several species of mycobacteria. Multi drug resistant strains of mycobacteria leading to the increase of patient world wide. There is an urgent need for new effective antimicrobial agent to replace those currently in use because of highly toxic. Screening methods available for discovering new chemical entities active against the resistant strains are detailed. The plant origin antimicrobial agents are the valuable anti tubercular drugs. The present review of patent stated several findings from an extensive literature search of semi synthetic, synthetic and natural plants that have been assessed for the antimicrobial activity over 20 years. An attempt has been made to summarize the information in order to highlight those chemical entities and plant species which are of worthy for further investigation as leads to the drug developments. Over 150 chemical entities of semi synthetic and synthetic and over 350 plant species from wide range of families containing various chemical classes of compounds have been cited here which are worthy for the researchers and the industrialist concerned to tuberculosis. The present review includes some patents relevant to the treatment of tuberculosis.

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Article Details

VOLUME: 3
ISSUE: 1
Page: [34 - 44]
Pages: 11
DOI: 10.2174/157489108783413209