Antifungal Activity of Goniothalamin Enantiomers
Angelo de Fatima,
Cleide Viviane Buzanello Martins,
Maria Aparecida de Resende,
Thais Furtado Ferreira Magalhaes,
Bruno Henrique Santiago Lima,
Gisele Almeida Watanabe,
Ana Lucia Tasca Gois Ruiz,
Joao Ernesto de Carvalho,
Ronaldo Aloise Pilli.
A large number of human diseases are caused by fungus and the plant kingdom has proven to be a source of antifungal compounds. This work describes the in vitro activity of the natural product (R)-goniothalamin and its synthetic enantiomer, (S)-goniothalamin, against eleven strains of human pathogenic fungi. The minimum inhibitory concentration (MIC) values for both enantiomers were lower than 100 μg/mL for nine of the fungus strains studied. MIC values for both enantiomers against isolates of the dimorphic fungus Paracoccidioides braziliensis were in the range of 7-22 μg/mL. (R)- and (S)- goniothalamin were selective for the fungi strains presenting minimal toxic effects on mammalian kidney (Vero) and lung (V79) cell lines.
Keywords: Fungi infections, Goniothalamus, Goniothalamin, Antifungal agents, Minimum inhibitory concentration, Antiproliferative activity
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