Inhibition of 17β -Hydroxysteroid Dehydrogenase (17β -HSD) by Imidazole-Based Compounds
Moniola S. Olusanjo,
Caroline P. Owen.
We report the results of the biochemical evaluation of a series of imidazole-based compounds against the hydroxysteroid dehydrogenase (HSD) family of enzymes, in particular, types 1 and 3 of 17β-HSD and 3β-HSD. The results show that the synthesised compounds were good inhibitors of this family of enzymes.
Keywords: Enzyme, Inhibition, Azole, Hydroxysteroid dehydrogenase, 17α-hydroxylase, 17,20-lyase
Rights & PermissionsPrintExport