Synthesis and Evaluation of N-Aryl 2-Aminothiazole-4-Carboxamide Derivatives for Activity Against TB
R. M. Riggs,
R. K. Jennings,
E. R. Derstine,
T. M. Nguyen,
J. M. Riordan.
Multi-drug resistant tuberculosis is a worldwide problem where despite treatment; mortality can range up to 18%. An N-aryl 2-aminothiazole-4-carboxamide derivative was identified as a lead compound in a Tuberculosis Coordinating Antimicrobial Acquisition Facility (TCAAF) screen. Synthesis and biological evaluation of additional analogs led to structure-activity relationships for activity against TB.
Keywords: Tuberculosis, Antimycobacterial, Structure-activity relationships
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