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Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Cancer Stem Cell Model in Oral Squamous Cell Carcinoma

Author(s): Zeng-Tong Zhou and Wei-Wen Jiang

Volume 3, Issue 1, 2008

Page: [17 - 20] Pages: 4

DOI: 10.2174/157488808783489426

Price: $65

Abstract

The concept of “field cancerization” describes the presence of histological abnormal tissue surrounding oral squamous cell carcinoma (OSCC). Molecular model of multistep carcinogenesis indicates that an accumulation of genetic alterations forms the basis for the OSCC progression with genetic heterogeneity. Furthermore, we reviewed cancer stem cell (CSC) model, which suggests functional heterogeneity in the tumor mass and current supporting evidence in OSCC. According to CSC model, prevention from carcinogen exposure and eliminating the particular CSCs instead of targeting tumor mass could help obtain a more long-lasting therapeutic effect.

Keywords: Cancer stem cell, oral squamous cell carcinoma, heterogeneity


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