Carbohydrate-Based Drugs in the Treatment of Epilepsy, Depression and Other Affective Disorders

Author(s): Cecilia H. Marzabadi, Ian Jamie Talisman.

Journal Name: Current Topics in Medicinal Chemistry

Volume 8 , Issue 2 , 2008

Become EABM
Become Reviewer

Abstract:

Mental illness affects a quarter of the US population. Recently, it has been shown that new, carbohydrate-based drugs hold promise in the treatment of central nervous system (CNS) disorders. A variety of ways in which drugs of this sort may reduce the symptoms of epilepsy, depression and other affective disorders have been proposed, including: targeting the immune system, disrupting glycolysis, acting at different sites in the hypothalamic-pituitary-adrenal (HPA) axis, and targeting specific biochemical pathways such as the inositol pathway. In the present review, the structureactivity relationships (SARs) of a wide variety of CNS-active carbohydrates are presented.

Keywords: Glycolysis, topiramate, saponins, steroidal glycosides, capsular saccharides

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 8
ISSUE: 2
Year: 2008
Page: [159 - 170]
Pages: 12
DOI: 10.2174/156802608783378846
Price: $58

Article Metrics

PDF: 5