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Current Topics in Medicinal Chemistry
ISSN (Print): 1568-0266
ISSN (Online): 1873-5294
VOLUME: 8
ISSUE: 2
DOI: 10.2174/156802608783378873      Price:  $58









Current Understanding on Biosynthesis of Microbial Polysaccharides

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Author(s): Peng George Wang, Hongjie Guo, Wen Yi and Jing K. Song
Pages 141-151 (11)
Abstract:
The surfaces of almost all microbes are decorated with remarkable variations of polysaccharides such as Oantigen, capsular polysaccharides (CPS), and exopolysaccharides (EPS) in bacteria, lipoarabinomannans (LAM) in mycobacteria and lipophosphoglycan (LPG) in Leishmania. These polysaccharides play important roles in many biological processes, and they can function as the virulence determinants in the pathogens. The basic structures of these polysaccharides are known, but they show species-specificity or stage-specificity. For example, there are 186 O-serotypes and 80 capsular serotypes in E. coli. Despite the variation, the range of strategies used for the biosynthesis and assembly of these microbial polysaccharides is limited. Depending on the assembly and translocation mechanisms, O-antigen biosynthesis is subdivided into three pathways, of which the Wzy-dependent pathway is widely used not only in Oantigen, but also in CPS and EPS.
Keywords:
O-antigen, Exopolysaccharide, Capsular Exopolysaccharide, Lipophosphoglycan
Affiliation:
Department of Biochemistry and Chemistry, The Ohio State University, Columbus, OH 43210.