Gastrin-Releasing Peptide Receptor as a Molecular Target for Inflammatory Diseases

Author(s): Felipe Dal Pizzol, Fabricia Petronilho, Rafael Roesler, Gilberto Schwartsmann.

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)

Volume 6 , Issue 4 , 2007

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Abstract:

Bombesin-like peptides (BLP) and its receptors are widely distributed in mammalian peripheral tissues and in the central nervous system. Recently, effects of these peptides on the production and release of cytokines were described both in animal models and humans with inflammatory diseases. Some pathological conditions such as exposure to tobacco smoke, chronic obstructive pulmonary diseases and eosinophilic granuloma have recently been found to be associated with an increase of pulmonary BLP-producing cells. Proinflammatory neuropeptides have a key role in the pathogenesis and maintenance of rheumatoid arthritis and sepsis. Together, these findings support the view that the GRPR should be considered a therapeutic target for a subset of inflammatory diseases.

Keywords: Neuropeptide, bombesin-like peptides, gastrin-releasing peptide receptor, immune system, sepsis

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Article Details

VOLUME: 6
ISSUE: 4
Year: 2007
Page: [197 - 200]
Pages: 4
DOI: 10.2174/187152807783334319
Price: $58

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