The Adipocyte as a Novel TSH Target

Author(s): A. Sorisky, T. T. Antunes, A. Gagnon.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 1 , 2008

Become EABM
Become Reviewer

Abstract:

Thyroid stimulating hormone (TSH; also known as thyrotropin), binds cognate receptors on the surface of thyrocytes to regulate proliferation and thyroid hormone synthesis. This unidimensional view of TSH is being transformed as new evidence indicates that TSH acts on adipose tissue. Adipocyte inflammatory responses that predispose to cardiovascular disease may occur in thyroid disorders associated with elevated TSH levels.

Keywords: TSH, TSH receptor, adipocyte, interleukin 6, leptin, cardiovascular disease

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 8
ISSUE: 1
Year: 2008
Page: [91 - 96]
Pages: 6
DOI: 10.2174/138955708783331531

Article Metrics

PDF: 18