Mini-Reviews in Medicinal Chemistry

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Essential Factors for Successful Virtual Screening

Author(s): Markus H.J. Seifert, Martin Lang.

Abstract:

Virtual high-throughput screening (vHTS) is a powerful technique for identifying hit molecules as starting points for medicinal chemistry. Numerous successful applications of vHTS have been published using a large variety of methodologies. This review attempts to identify the essential factors for successful virtual screening in the hit identification phase.

Keywords: Virtual screening, high-throughput screening, docking, scoring, hit identification, similarity search

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2008
Page: [63 - 72]
Pages: 10
DOI: 10.2174/138955708783331540