Targeting the Viral Nucleocapsid Protein in Anti-HIV-1 Therapy

Author(s): Yves Mely, Hugues de Rocquigny, Volodymyr Shvadchak, Sergiy Avilov, Chang Zhi Dong, Ursula Dietrich, Jean-Luc Darlix.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 1 , 2008

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Abstract:

The nucleocapsid protein (NC) plays seminal roles in HIV replication, thus representing a major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc ejectors inhibit NC functions, but with limited specificity. New classes of molecules competing with NC or its viral nucleic acid and enzyme partners are reviewed here.

Keywords: NCp7, zinc ejector, library, HIV, structure, peptidomimetic, aptamer, intercalator

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2008
Page: [24 - 35]
Pages: 12
DOI: 10.2174/138955708783331603

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