A Facile Synthesis of Polyhydroquinoline Derivatives via the Hantzsch Reaction Under Solvent Free-Conditions Using Potassium Dodecatungsto Cobaltate Trihydrate (K5CoW12O40.3H2O)

Author(s): Lingaiah Nagarapu, Satyender Apuri, Subhashini Gaddam, Rajashaker Bantu, Venu C. Mahankhali, Srinivas Kantevari.

Journal Name:Letters in Organic Chemistry

Volume 5 , Issue 1 , 2008

Abstract:

A facile and efficient one-pot synthesis of polyhydroquinoline derivatives via the Hantzsch reaction using a variety of aldehydes, 5,5-dimethyl-1,3-cyclohexanedione or 1,3-cyclohexanedione, ethyl acetoacetate, and ammonium acetate in the presence of potassium dodecatungstocobaltate trihydrate [K5CoW12O40. 3H2O] as a heterogeneous catalyst in a solvent-free media at 90 °C is described herein . The present methodology offers several advantages such as excellent yields, simple procedure, shorter reaction times (10-25 min.), milder conditions and the catalyst exhibited remarkable reusability.

Keywords: Potassium dodecatungstocobaltate.trihydrate, 5,5-dimethyl-1,3-cyclohexanedione, 1,3-cyclohexanedione, solventfree media, polyhydroquinoline reusability

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Article Details

VOLUME: 5
ISSUE: 1
Year: 2008
Page: [60 - 64]
Pages: 5
DOI: 10.2174/157017808783330162

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