Copper(I) Bromide Promoted Selective Reduction of N-substituted Phthalimides with Zinc

Author(s): Lixin Wang, Jiyu Wang, Fan Yang, Jianfeng Shen, Wen Wang.

Journal Name:Letters in Organic Chemistry

Volume 5 , Issue 1 , 2008

Abstract:

A new selective reduction of N-substituted phthalimides to the corresponding hydroxyl lactams is described. This reduction performed smoothly under mild, concise and easily controllable condition in good yield (up to 97%). The generality of the reduction was also investigated and a wide range of substrates were suitable for this reaction.

Keywords: Phthalimide, hydroxyphalimidines, zinc, copper (I) bromide, reduction

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Article Details

VOLUME: 5
ISSUE: 1
Year: 2008
Page: [26 - 29]
Pages: 4
DOI: 10.2174/157017808783330171

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