S-adenosylmethionine is a metabolite regulating many biological processes; S-adenosylmethionine effect on ubiquitin-proteasome system (UPS) has not been studied yet. We investigated S-adenosylmethionine effects on UPS activity both in vitro, by inhibitor screening assay, and in rat vascular smooth muscle cells, by Western Blot of proteasomal targets. We found that S-adenosylmethionine inhibited UPS activity.
Keywords: Ubiquitin-proteasome system, 20S proteasome, S-adenosylmethionine, vascular smooth muscle cells, atherosclerosis, Sulfur-containing aminoacids cycle
Rights & PermissionsPrintExport