Abstract
During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the γ-carboxylation of the Glu-42 (Gla- 42).
Keywords: γ-Carboxy-glutamate, cerebrospinal fluid, moyamoya disease, post-translational modification, human transthyretin, two-dimensional gel electrophoresis
Protein & Peptide Letters
Title: Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin
Volume: 15 Issue: 1
Author(s): Thomas Franz, Sabrina Ruggeberg, Peter Horn, Xinping Li and Peter Vajkoczy
Affiliation:
Keywords: γ-Carboxy-glutamate, cerebrospinal fluid, moyamoya disease, post-translational modification, human transthyretin, two-dimensional gel electrophoresis
Abstract: During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the γ-carboxylation of the Glu-42 (Gla- 42).
Export Options
About this article
Cite this article as:
Franz Thomas, Ruggeberg Sabrina, Horn Peter, Li Xinping and Vajkoczy Peter, Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin, Protein & Peptide Letters 2008; 15 (1) . https://dx.doi.org/10.2174/092986608783330297
DOI https://dx.doi.org/10.2174/092986608783330297 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Composite Lymphomas: A Challenging Entity
Current Cancer Therapy Reviews Intracellular Signaling of the Aging Suppressor Protein Klotho
Current Molecular Medicine Recent Progress in Pharmacological Research of Antioxidants in Pathological Conditions: Cardiovascular Health
Recent Patents on Anti-Infective Drug Discovery Anti-Atherosclerotic Therapy Based on Botanicals
Recent Patents on Cardiovascular Drug Discovery Synthesis and Biological Evaluation of Curcumin-Nitroxide-Based Molecular Hybrids as Antioxidant and Anti-Proliferative Agents
Medicinal Chemistry Donors of HNO
Current Topics in Medicinal Chemistry Epoxyeicosatrienoic Acid Analogs and Vascular Function
Current Medicinal Chemistry Exploring Pharmacological Significance of Chalcone Scaffold: A Review
Current Medicinal Chemistry Separating Fact from Fiction: Assessing the Potential of Modified Adenovirus Vectors for Use in Human Gene Therapy
Current Gene Therapy Arterial Stiffness As A Therapeutic Target For Isolated Systolic Hypertension: Focus on Vascular Calcification and Fibrosis
Current Hypertension Reviews Delivery of Neurotherapeutics Across the Blood Brain Barrier in Stroke
Current Pharmaceutical Design Computed Tomographic Angiography for Risk Stratification in Patients with Acute Chest Pain - The Triple Rule-out Concept in the Emergency Department
Current Medical Imaging Oxidized Haemoglobin–Driven Endothelial Dysfunction and Immune Cell Activation: Novel Therapeutic Targets for Atherosclerosis
Current Medicinal Chemistry Thrombotic Microangiopathy and Occult Neoplasia
Cardiovascular & Hematological Disorders-Drug Targets Involvement of Cytokines and Inflammation in Catecholamine-Induced Pulmonary Injury in Rats
Vascular Disease Prevention (Discontinued) Increasing Bcl-2 and Neuroglubin Expression in Hypoxic Hippocampal Neurons under Hypoxia Preconditioning and in 3-n-butylphalide Treated Cells under Oxygen Glucose Deprivation/Reoxygenation
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Reperfusion Therapies in Acute Ischemic Stroke
Recent Patents on CNS Drug Discovery (Discontinued) Natriuretic Peptide Signaling via Guanylyl Cyclase (GC)-A: An Endogenous Protective Mechanism of the Heart
Current Cardiology Reviews Use of Exogenous Enzymes in Human Therapy: Approved Drugs and Potential Applications
Current Medicinal Chemistry Mediterranean Diet and Oxidation: Nuts and Olive Oil as Important Sources of Fat and Antioxidants
Current Topics in Medicinal Chemistry