APP-Based Neuroprotective Strategies

Author(s): Dale E. Bredesen , Shahrooz Rabizadeh .

Journal Name: Current Alzheimer Research

Volume 4 , Issue 5 , 2007

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While much of the focus on Alzheimers disease therapeutics has been directed at beta-amyloid peptide or at cholinergic synaptic transmission, recent data suggest that targeting signal transduction by the amyloid precursor protein (APP) itself may be an alternative approach with significant potential [1]. Here we discuss the possibility that APPmediated signal transduction, downstream from amyloid-beta peptide production itself, may be an appropriate therapeutic target in Alzheimers disease.

Keywords: amyloid precursor protein interactors, Alzheimers disease, degenerating neuron, misfolded proteins, caspase

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Article Details

Year: 2007
Page: [541 - 543]
Pages: 3
DOI: 10.2174/156720507783018253
Price: $58

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