Novel Multifunctional Anti-Alzheimer Drugs with Various CNS Neurotransmitter Targets and Neuroprotective Moieties

Author(s): Cornelis J. Van der Schyf , Silvia Mandel , Werner J. Geldenhuys , Tamar Amit , Yael Avramovich , Hailin Zheng , Mati Fridkin , Shunit Gal , Orly Weinreb , Orit Bar Am , Yotam Sagi , Moussa B.H. Youdim .

Journal Name: Current Alzheimer Research

Volume 4 , Issue 5 , 2007

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Abstract:

Traditionally, drug design programs are focused on optimizing the specificity of lead compounds against a carefully selected drug target. Disappointingly, this approach to discover a “magic bullet” drug has not met with the expected success for CNS disorders. Transcriptomics and proteomic profiling of neurodegenerative diseases have indicated that they are poly-etiological in origin and that the processes leading to neuronal death are multifactorial. An emerging concept is the design of drug ligands that modulate multiple drug targets identified for a particular disease. In this review we explore some examples of multifunctional drugs which may be useful in the treatment of neurodegenerative diseases, such as Alzheimers and Parkinsons disease.

Keywords: NMDA receptor, Deferoxamine, reactive oxygen species, MAO-B inhibitor, Neuronal nitric oxide

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Article Details

VOLUME: 4
ISSUE: 5
Year: 2007
Page: [522 - 536]
Pages: 15
DOI: 10.2174/156720507783018226
Price: $58

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