Combretastatin A-4 Analogs as Anticancer Agents

Author(s): Anurag Chaudhary , S. N. Pandeya , P. Kumar , P. P. Sharma , S. Gupta , N. Soni , K. K. Verma , G. Bhardwaj .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 12 , 2007

Become EABM
Become Reviewer

Abstract:

Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.

Keywords: Combretastatin A-4, antitubulin, antivascular, cytotoxicity, structure-activity relationship

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 7
ISSUE: 12
Year: 2007
Page: [1186 - 1205]
Pages: 20
DOI: 10.2174/138955707782795647
Price: $58

Article Metrics

PDF: 14