A Facile Synthesis of Lipo-Chitopentaose Nodulation Factor

Author(s): G.-L. Huang, Kongliang Wong.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 8 , 2007

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We prepared the penta-N-acetyl-chitopentaose 2 by using recombinant Escherichia coli (E. coli) strains harboring the nodC gene (encoding chitooligosaccharide synthase) from Azorhizobium caulinodans. The deacetylase NodB removed the N-acetyl moiety from the nonreducing terminus of 2 to give tetra-N-acetyl-chitopentaose 3. N-Acylation of 3 with stearyl chloride was performed in DMF containing water and provided the corresponding lipo-chitopentaose nodulation factor 4.

Keywords: Lipo-chitopentaose nodulation factor, chemo-enzymatic synthesis, degradation velocity, chitinase

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Article Details

Year: 2007
Page: [588 - 589]
Pages: 2
DOI: 10.2174/157017807782795475
Price: $65

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