The Modular Synthesis of Chiral N-Heterocyclic Carbene Precursors

Title: The Modular Synthesis of Chiral N-Heterocyclic Carbene Precursors

Volume: 4 Issue: 8

Author(s): Attila Paczal and Andras Kotschy

Affiliation:

Keywords: Heterocyclic carbenes, chirality, chiral amines, ring closure, imidazolium salts

Abstract: A series of chiral N-heterocyclic carbene precursors based on the dihydroimidazole framework were prepared from easily available chiral amines. The sequential attachment of these amines and mesitylamine to chloroacetyl chloride followed by reduction and subsequent ring closure gave the desired dihydroimidazolium salts in good yield.

Cite this article as:

Paczal Attila and Kotschy Andras, The Modular Synthesis of Chiral N-Heterocyclic Carbene Precursors, Letters in Organic Chemistry 2007; 4 (8) . https://dx.doi.org/10.2174/157017807782795565