Synthesis of Multivalent Galactosides with High Affinity for the Hepatic Asialoglycoprotein Receptor

Author(s): Li Hai, Jiao Lu, Zhi-Rong Zhang, Shou-Zhu Liao, Jin-Cheng Yang, Yong Wu.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 8 , 2007

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A series of bifunctional compounds carrying cluster thiogalactosides L1-L6 as the cell targeting ligands were synthesized for gene delivery to hepatocytes. Tetra-antennary dendr-OMs4 5 was used as a scaffold for the attachment of three galactosides, while the other mesylate end was linked with cholesterol through poly(ethylene glycol) chain with different length. This design provided an effective entry for the synthesis of the bifunctional compound with hepatocytes targeting ability.

Keywords: Cluster, cholesterylated galactosides, targeting ligand, hepatocyte specific delivery, gene delivery

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Article Details

Year: 2007
Page: [559 - 562]
Pages: 4
DOI: 10.2174/157017807782795510
Price: $65

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