Synthesis of Multivalent Galactosides with High Affinity for the Hepatic Asialoglycoprotein Receptor

Title: Synthesis of Multivalent Galactosides with High Affinity for the Hepatic Asialoglycoprotein Receptor

Volume: 4 Issue: 8

Author(s): Li Hai, Jiao Lu, Zhi-Rong Zhang, Shou-Zhu Liao, Jin-Cheng Yang and Yong Wu

Affiliation:

Keywords: Cluster, cholesterylated galactosides, targeting ligand, hepatocyte specific delivery, gene delivery

Abstract: A series of bifunctional compounds carrying cluster thiogalactosides L1-L6 as the cell targeting ligands were synthesized for gene delivery to hepatocytes. Tetra-antennary dendr-OMs4 5 was used as a scaffold for the attachment of three galactosides, while the other mesylate end was linked with cholesterol through poly(ethylene glycol) chain with different length. This design provided an effective entry for the synthesis of the bifunctional compound with hepatocytes targeting ability.

Cite this article as:

Hai Li, Lu Jiao, Zhang Zhi-Rong, Liao Shou-Zhu, Yang Jin-Cheng and Wu Yong, Synthesis of Multivalent Galactosides with High Affinity for the Hepatic Asialoglycoprotein Receptor, Letters in Organic Chemistry 2007; 4 (8) . https://dx.doi.org/10.2174/157017807782795510