Total Synthesis of (±)-Euryfuran Through Ti(III) Catalyzed Radical Cyclization

Title: Total Synthesis of (±)-Euryfuran Through Ti(III) Catalyzed Radical Cyclization

Volume: 4 Issue: 8

Author(s): Antonio Rosales, Cristobal Lopez-Sanchez, Miriam Alvarez-Corral, Manuel Muooz-Dorado and Ignacio Rodriguez-Garcia

Affiliation:

Keywords: Titanium, radical reactions, cyclization, diastereoselectivity, farnesol, furanosesquiterpenes

Abstract: A concise total synthesis of the furano-sesquiterpene (±)-euryfuran, a bioactive metabolite from some marine sponges, is presented. The key step is a highly diastereoselective titanium (III) catalyzed radical cyclization of a farnesol epoxyderivative.

Cite this article as:

Rosales Antonio, Lopez-Sanchez Cristobal, Alvarez-Corral Miriam, Muooz-Dorado Manuel and Rodriguez-Garcia Ignacio, Total Synthesis of (±)-Euryfuran Through Ti(III) Catalyzed Radical Cyclization, Letters in Organic Chemistry 2007; 4 (8) . https://dx.doi.org/10.2174/157017807782795457