Title: Excellent Exo/Endo-Selectivity in the 1,3-Dipolar Cycloaddition of Cyclic Azomethine Ylide: Exploring the Facile Investigation of Cocaine Antagonists
VOLUME: 4 ISSUE: 8
Author(s):Joydev K. Laha
Affiliation:Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune-411008, India.
Keywords:Cocaine antagonists, tropane, 1,3-dipolar cycloaddition, cyclic azomethine ylide, exo/endo-selectivity
Abstract: High exo-selectivity was achieved in the 1,3-dipolar cycloaddition of a cyclic azomethine ylide and phenyl vinyl sulfone or Opplozers camphorsultam chiral dipolarophile leading to the synthesis of two novel tropane compounds.
