Preparation of an Artificial Ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a Base and its Discriminating Ability for Natural Nucleosides

Author(s): Taisuke Hirano, Kenji Kuroda, Hidehiko Kodama, Masanori Kataoka, Yoshihiro Hayakawa.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 8 , 2007

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An artificial ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone (PPT) as a nucleobase was prepared, and its binding affinity for natural nucleosides, e.g., 2-deoxyadenosine, 2-deoxycytidine, 2- deoxyguanosine, and thymidine derivatives, was investigated. This investigation revealed that, as expected, the nucleoside with PPT has good binding affinity for the four natural nucleosides to form with them some stable complexes in dimethyl sulfoxide, though the structure of the complex is not clear yet. Thus, this artificial nucleoside has high potential as a universal nucleoside.

Keywords: Nucleosides, nitrogen heterocycles, tautomerism

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Article Details

Year: 2007
Page: [530 - 534]
Pages: 5
DOI: 10.2174/157017807782795493
Price: $65

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