Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Design and Synthesis of a (N-Alkylaminoalkyl-Substituted)Arylalkenylamide Drug Discovery Library

Author(s): M. Urbano, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro, A. Artese, O. Azzolina.

Abstract:

To discover new potential sigma ligands, a library of 64 members based on a carbamidic scaffold was designed and a synthetic protocol, based on PASPS and MAOS techniques, was developed and optimized. Applying the developed protocol the library compounds were obtained in high purity, suitable for biological screening.

Keywords: Discovery library, Sigma ligands, Arylalkenylamidic scaffold, PASPS, MAOS, Molecular modeling

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Article Details

VOLUME: 4
ISSUE: 8
Year: 2007
Page: [605 - 610]
Pages: 6
DOI: 10.2174/157018007782794581
Price: $58