Design and Synthesis of a (N-Alkylaminoalkyl-Substituted)Arylalkenylamide Drug Discovery Library
A. Carnevale Baraglia,
To discover new potential sigma ligands, a library of 64 members based on a carbamidic scaffold was designed and a synthetic protocol, based on PASPS and MAOS techniques, was developed and optimized. Applying the developed protocol the library compounds were obtained in high purity, suitable for biological screening.
Keywords: Discovery library, Sigma ligands, Arylalkenylamidic scaffold, PASPS, MAOS, Molecular modeling
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