Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents

Author(s): Ahmed Kamal, S. Kaleem Ahmed, K. Srinivasa Reddy, M. Naseer A. Khan, Rajesh V.C.R.N.C. Shetty, B. Siddhardha, U. S.N. Murty, Arnab China, V. Nagaraja.

Abstract:

A new series of benzothiazolo-benzothiadiazine hybrids (9a-g) has been synthesized and evaluated for their antibacterial activity against clinical isolates of Gram-positive and Gram-negative bacteria. Some of these hybrids in this series exhibited antibacterial activity comparable to ampicillin. In addition, some of the compounds showed DNA gyrase inhibitory activity at a moderate level compared to ciprofloxacin.

Keywords: Benzothiadiazines, Benzothiazoles, Antibacterial activity, DNA gyrase inhibition

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Article Details

VOLUME: 4
ISSUE: 8
Year: 2007
Page: [550 - 556]
Pages: 7
DOI: 10.2174/157018007782794563
Price: $58