Abstract
Although the use of stem cells in cell-replacement therapies by transplantation is obvious, another equally important and interesting application of stem cells is to use them in disease modeling. Disease models serve as a platform to dissect the biochemical mechanisms of normal phenotypes and the processes which go awry during disease conditions. Particularly in complex, multigenic diseases, molecular studies lead to a greater understanding of the disease, and perhaps more targeted approaches for therapies. Stem cells provide an ideal in vitro system in which to study events related to development at the molecular and cellular level. Neural stem cells have been used as excellent models to study the mechanisms of differentiation of cells of the central nervous system. These studies may be particularly relevant to diseases of complex etiology such as psychiatric illnesses, neurodegenerative diseases and brain tumors. Stem cell-derived systems are also being developed to create models of cardiovascular disease. The application of stem cells to the study of cardiovascular illnesses, and vertebrate heart development, is discussed.
Keywords: Stem cells, embryonic, neural, cardiac, autism, glioma
Current Stem Cell Research & Therapy
Title: Stem Cells as In Vitro Models of Disease
Volume: 2 Issue: 4
Author(s): Pilar Ruiz-Lozano and Prithi Rajan
Affiliation:
Keywords: Stem cells, embryonic, neural, cardiac, autism, glioma
Abstract: Although the use of stem cells in cell-replacement therapies by transplantation is obvious, another equally important and interesting application of stem cells is to use them in disease modeling. Disease models serve as a platform to dissect the biochemical mechanisms of normal phenotypes and the processes which go awry during disease conditions. Particularly in complex, multigenic diseases, molecular studies lead to a greater understanding of the disease, and perhaps more targeted approaches for therapies. Stem cells provide an ideal in vitro system in which to study events related to development at the molecular and cellular level. Neural stem cells have been used as excellent models to study the mechanisms of differentiation of cells of the central nervous system. These studies may be particularly relevant to diseases of complex etiology such as psychiatric illnesses, neurodegenerative diseases and brain tumors. Stem cell-derived systems are also being developed to create models of cardiovascular disease. The application of stem cells to the study of cardiovascular illnesses, and vertebrate heart development, is discussed.
Export Options
About this article
Cite this article as:
Ruiz-Lozano Pilar and Rajan Prithi, Stem Cells as In Vitro Models of Disease, Current Stem Cell Research & Therapy 2007; 2 (4) . https://dx.doi.org/10.2174/157488807782793772
DOI https://dx.doi.org/10.2174/157488807782793772 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Advanced Echocardiographic Imaging of the Congenitally Malformed Heart
Current Cardiology Reviews New Insights in Congenital Diaphragmatic Hernia
Current Respiratory Medicine Reviews Pathophysiology of Post-Operative Low Cardiac Output Syndrome
Current Vascular Pharmacology Sedation and Analgesia in Pediatric Intensive Care
Current Drug Targets Genomic and Epigenetic Complexity of the FOXF1 Locus in 16q24.1: Implications for Development and Disease
Current Genomics Inflammatory Mediators and the Failing Heart: A Translational Approach
Current Molecular Medicine Rational Autologous Cell Sources For Therapy of Heart Failure - Vehicles and Targets For Gene and RNA Therapies
Current Gene Therapy Structural Chromosome Abnormalities Associated with Obesity: Report of Four New Subjects and Review of Literature
Current Genomics Therapeutic Utilities of Pediatric Cardiac Catheterization
Current Cardiology Reviews Cardiac Resynchronization Therapy in Children
Current Cardiology Reviews Near Infrared Optical Technologies to Illuminate the Status of the Neonatal Brain
Current Pediatric Reviews Adenoid Hypertrophy, Craniofacial Growth and Obstructive Sleep Apnea: A Crucial Triad in Children
Current Respiratory Medicine Reviews Role of Genetic Factors in the Pathogenesis of Radial Deficiencies in Humans
Current Genomics Advances in the Molecular Genetics of Non-syndromic Syndactyly
Current Genomics Retinoid-Induced Limb Malformations
Current Pharmaceutical Design Congenital Malformations Attributed to Prenatal Exposure to Cyclophosphamide
Anti-Cancer Agents in Medicinal Chemistry Pulmonary Circulation and Pulmonary Function in Neonatal Lung Hypoplasia:Treatment with Corticosteroids
Current Pediatric Reviews Atrial Tachycardias Occurring Late After Open Heart Surgery
Current Cardiology Reviews Neonatology in the United States: Where we are, and where we are Going
Current Pediatric Reviews Current Outcomes and Considerations in Hypoplastic Left Heart Syndrome
Current Pediatric Reviews