Abstract
Regenerative medicine opens new avenues and promises towards more effective therapies for autoimmune disorders. Current therapeutic strategies for type I diabetes focus on three major directions, with distinct advantages and disadvantages: arrest of autoimmunity, islet transplantation and generation of neoislets. There is mounting evidence that candidate stem cells residing in the hematopoietic compartments participate in regeneration of pancreatic islets following chemical and autoimmune injury in vivo. The apparent major mechanisms include immunomodulation, revascularization, support of endogenous β-cell regeneration and differentiation into insulin-producing cells. Review of the current evidence suggests that some divergent observations depend primarily on the experimental design, which both limits and accentuates developmental events. The flood of publications reporting negative results appears to reflect primarily suboptimal experimental conditions for differentiation of putative stem cells, rather than limited developmental plasticity. Stem cells modulate the course of autoimmune diabetes through multiple mechanisms, including de novo generation of units capable to sense, produce and secrete insulin. Therefore, the charged debate over controversies surrounding developmental plasticity should not impede attempts to design curative therapies for this disease.
Keywords: autoimmunity, green fluorescent ptotein, streptozotocin, immunogenic, hematopoietic potential
Current Stem Cell Research & Therapy
Title: Participation of Adult Bone Marrow-Derived Stem Cells in Pancreatic Regeneration: Neogenesis Versus Endogenesis
Volume: 2 Issue: 4
Author(s): Svetlana Iskovich, Ayelet Kaminitz, Michal Pearl Yafe, Keren Mizrahi, Jerry Stein, Isaac Yaniv and Nadir Askenasy
Affiliation:
Keywords: autoimmunity, green fluorescent ptotein, streptozotocin, immunogenic, hematopoietic potential
Abstract: Regenerative medicine opens new avenues and promises towards more effective therapies for autoimmune disorders. Current therapeutic strategies for type I diabetes focus on three major directions, with distinct advantages and disadvantages: arrest of autoimmunity, islet transplantation and generation of neoislets. There is mounting evidence that candidate stem cells residing in the hematopoietic compartments participate in regeneration of pancreatic islets following chemical and autoimmune injury in vivo. The apparent major mechanisms include immunomodulation, revascularization, support of endogenous β-cell regeneration and differentiation into insulin-producing cells. Review of the current evidence suggests that some divergent observations depend primarily on the experimental design, which both limits and accentuates developmental events. The flood of publications reporting negative results appears to reflect primarily suboptimal experimental conditions for differentiation of putative stem cells, rather than limited developmental plasticity. Stem cells modulate the course of autoimmune diabetes through multiple mechanisms, including de novo generation of units capable to sense, produce and secrete insulin. Therefore, the charged debate over controversies surrounding developmental plasticity should not impede attempts to design curative therapies for this disease.
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Iskovich Svetlana, Kaminitz Ayelet, Yafe Pearl Michal, Mizrahi Keren, Stein Jerry, Yaniv Isaac and Askenasy Nadir, Participation of Adult Bone Marrow-Derived Stem Cells in Pancreatic Regeneration: Neogenesis Versus Endogenesis, Current Stem Cell Research & Therapy 2007; 2 (4) . https://dx.doi.org/10.2174/157488807782793754
DOI https://dx.doi.org/10.2174/157488807782793754 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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