Spectroscopic and Functional Characterization of Human β-Synuclein

Author(s): Juhyung Lee, Heejin Hwang, T. Doohun Kim.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 10 , 2007

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Abstract:

To elucidate potential biological roles of human β-synuclein, we studied its conformational changes under various conditions. The structural and functional properties of β-synuclein were characterized using biochemical and biophysical methods including: a functional assay, mass spectrometry, size exclusion chromatography, circular dichroism (CD), and fluorescence spectroscopy. The results showed β-synuclein has a high proportion of random coil in solution.

Keywords: β-Synuclein, circular dichroism, fluorescence, conformational change

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Article Details

VOLUME: 14
ISSUE: 10
Year: 2007
Page: [1021 - 1026]
Pages: 6
DOI: 10.2174/092986607782541132
Price: $65

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