Translating Genetic Findings into Therapy in Parkinson Disease

Author(s): Sagrario M. Palomo, Adriano Jimenez-Escrig.

Journal Name: Recent Patents on CNS Drug Discovery (Discontinued)

Volume 2 , Issue 3 , 2007

Abstract:

In the last decade, current opinion for Parkinson disease (PD) etiology has swung from the hypothesis of a toxic/environmental disorder to understanding it as a highly heritable condition. Recent research conducted in families affected from PD has disclosed 6 genes that codify for proteins in pathways of neurodegeneration in PD. This review focuses in new drugs aimed to prevent the apparition and progression of the disease developed after the knowledge obtained from the genetic studies of PD, covering most recent and important patents.

Keywords: Synuclein, parkin, LRRK2, proteasome

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2007
Page: [229 - 237]
Pages: 9
DOI: 10.2174/157488907782411747
Price: $58