Current Rheumatology Reviews

Dr. Serena Guiducci  
Department of Biomedicine, Division of Rheumatology
University of Florence
Florence
Italy

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Clinical Relevance of Cytokines and Inflammatory Molecules in Rheumatoid Vasculitis

Author(s): Tsuyoshi Kasama, Mizuho Matsunawa, Kuninobu Wakabayashi, Yusuke Miwa.

Abstract:

Rheumatoid vasculitis (RV) is an uncommon but severe complication of rheumatoid arthritis (RA) that can cause skin disorders, such as rash, cutaneous ulcerations and gangrene, neuropathy, eye symptoms, and systemic inflammation. Although the molecular mechanisms underlying RV in RA are unclear, it is well known that a chronic imbalance in the expression of chemokines and proinflammatory cytokines is important for orchestrating inflammatory responses in RA patients, and similar dysregulation of cytokines and other inflammatory molecules, such as adhesion molecules, has been suggested to occur in patients with RV. Recently, we reported elevated levels of the soluble form of CX3CL1, which is a newly described membrane-bound CX3C chemokine, in the serum of patients with RV. In the present review, we discuss the involvement of cytokines and inflammatory molecules in the pathogenesis of RV and evaluate their significance as useful laboratory parameters of active vasculitis disease.

Keywords: Rheumatoid vasculitis, cytokines, chemokines, adhesion molecules, CX3CL1, endothelium

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2007
Page: [309 - 316]
Pages: 8
DOI: 10.2174/157339707782408919
Price: $58