Current Pediatric Reviews

Giuseppe Buonocore
Department of Molecular and Developmental Medicine
University of Siena
Siena
Italy

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The Role of Inflammation in Epilepsy

Author(s): Alberto Verrotti, Giuseppe Latini, Alessandra Scardapane, Rossella Manco, Antonio Del Vecchio.

Abstract:

Experimental and clinical data suggest that activation of inflammation may occur after epileptic seizures without any evidence of systemic or central nervous system infection. Various animal and human studies have recently shown that cytokines are involved in the pathogenesis of epilepsy. Although little is known about the role of inflammation in epilepsy, it has been hypothesized that activated immune system and subsequent inflammatory reaction in the brain can intervene to facilitate certain molecular and structural changes occurring during and after seizure activity. This review focuses on the relationship between inflammation and epilepsy.

Keywords: blood-brain barrier, tumor necrosis factor alpha, Seizures, corticotropin releasing hormone, Temporal lobe epilepsy

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2007
Page: [312 - 316]
Pages: 5
DOI: 10.2174/157339607782411538
Price: $58