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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

A Role of the 9-Aminoacridines and their Conjugates in a Life Science

Author(s): Jaroslav Sebestik, Jan Hlavacek and Ivan Stibor

Volume 8, Issue 5, 2007

Page: [471 - 483] Pages: 13

DOI: 10.2174/138920307782411400

Price: $65

Abstract

The 9-aminoacridines play an important role in medicine. They were applied first in a treatment of protozoal infections in the beginning of the last century. Recently, it has been shown that the 9-aminoacridines are successful candidates for treatment of cancer, viral and prion diseases. Their conjugation with biomolecules such as peptides and proteins may modulate their activity, bioavailability and applicability. This review deals with the synthesis of 9-aminoacridine, its conjugation with variety of molecules and utilization of such conjugates in several fields of science.

Keywords: Acridines, 9-aminoacridine, conjugates, nucleic acids, proteins


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