Current Nutrition & Food Science

Undurti N. Das  
UND Life Sciences
Shaker Heights
OH 44120


Vitamin E does not Support Bone Quality in Orchidectomized Rats

Author(s): Farzad Deyhim, Claudia Garcia, Arnulfo Villarreal, Kristi Garcia, Ryan Rios, Cheri Gonzales, Kranthi Mandadi, Bahram Faraji, Bhimanagouda S. Patil.


Vitamin E is known to improve antioxidant status, but the effect of vitamin E on bone quality in orchidectomized rats is unknown. In the present study, thirty-two 1-y-old male rats were randomized to two groups: a sham-control group (n=8) and an orchidectomized group (n=24). The orchidectomized group was divided into three groups of eight and assigned to one of the following treatments: orchidectomy (ORX), low-dose vitamin E of 65.6 mg/Kg diet or high-dose vitamin E of 656 mg/Kg diet. Four months after the study began, all rats were killed, blood was collected, and plasma was harvested for antioxidant status, tartrate resistant acid phosphatase (TRAP), and IGF-I. Orchidectomy decreased (P < 0.05) plasma antioxidant and IGF-I, reduced bone (P < 0.05) quality and bone strength, increased (P < 0.05) plasma TRAP and urinary excretion of calcium and magnesium compared to the sham-control group. In contrast to ORX, vitamin E increased (P < 0.05) plasma antioxidant and had no beneficial effect on indices of bone quality, bone resorption and bone formation marker, or urinary calcium and magnesium excretion. In conclusion, vitamin E appears to decrease oxidative stress without improving bone quality in orchidectomized rats.

Keywords: Antioxidants, oxidative stress, vitamin E, bone

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Article Details

Year: 2007
Page: [300 - 303]
Pages: 4
DOI: 10.2174/1573401310703040300
Price: $58