Bioinformatics Analysis of Functional Protein Sequences Reveals a Role for Tumor Necrosis Factor-α and Nitric Oxide in Insulin Resistance Syndrome

Author(s): Appa Rao Allam , Hanuman Thota , Srihari Ramisetti , Kodanda R.K.R. Tirumala , Sridhar R. Gumpeny , Annapurna Akula , Suresh Babu Changalasetty , Siva Reddy Challa , Veera Swamy Thota , V. V. Satyanarayana Kopparthi , Undurt N. Das .

Journal Name: Current Nutrition & Food Science

Volume 3 , Issue 4 , 2007

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Using bioinformatics techniques and sequence analyses algorithms, we identified that tumor necrosis factor-α (TNF-α) and nitric oxide (NO) have a significant role in the pathobiology of insulin resistance syndrome, a condition that is common in subjects with abdominal obesity, hypertension, dyslipidemia, atherosclerosis, and coronary heart disease and are accompanied by endothelial dysfunction due to reduced endothelial nitric oxide generation. TNF-α has neurotoxic actions, stimulates inducible NO synthase activity, and modulates the expression of neurotransmitters involved in the control of feeding and thermogenesis. NO is a neurotransmitter and influences secretion and actions of various hypothalamic peptides and neuropeptides. Insulin suppresses the production of TNF-α but stimulates that of endothelial NO. This close interaction between TNF-α, NO, hypothalamic peptides, and insulin suggests that regulation of TNF-α and NO production and action could be critical in the management of insulin resistance syndrome and its associated conditions.

Keywords: Insulin resistance, tumor necrosis factor, nitric oxide, hypothalamus, neurotransmission, insulin, endothelium, inflammation

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Article Details

Year: 2007
Page: [250 - 254]
Pages: 5
DOI: 10.2174/1573401310703040250
Price: $58

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