Abstract
The sequence of a protein normally determines which amino acid residues will form a helices, and which one b sheets, to an extent that allows secondary structure prediction to be made with a reasonable reliability. Nevertheless, non-native helical structures are observed during in vitro folding of several model proteins and may even occur during protein biosynthesis within the ribosomal exit tunnel. Moreover, non-native b sheet structures are common in amyloid fibrils formed by a variety of pathogenic and even non-pathogenic proteins and peptides. In all of these cases, the formation of a helix precedes the appearance of b sheet, which suggests that conversion from the simpler, more local helix structure to the often more convoluted sheet architecture during folding and pathogenic misfolding processes could be a unifying principle of general importance. A better understanding of this switching process, and the ability to design molecular systems which can be induced to switch between these conformations will have a significant impact on fields ranging from fundamental biochemistry through to applied technology and medicine.
Keywords: Helix, helical native, amyloid, transthyretin
Current Protein & Peptide Science
Title: Proteins that Convert from a Helix to b Sheet Implications for Folding and Disease
Volume: 1 Issue: 4
Author(s): Michael GroB
Affiliation:
Keywords: Helix, helical native, amyloid, transthyretin
Abstract: The sequence of a protein normally determines which amino acid residues will form a helices, and which one b sheets, to an extent that allows secondary structure prediction to be made with a reasonable reliability. Nevertheless, non-native helical structures are observed during in vitro folding of several model proteins and may even occur during protein biosynthesis within the ribosomal exit tunnel. Moreover, non-native b sheet structures are common in amyloid fibrils formed by a variety of pathogenic and even non-pathogenic proteins and peptides. In all of these cases, the formation of a helix precedes the appearance of b sheet, which suggests that conversion from the simpler, more local helix structure to the often more convoluted sheet architecture during folding and pathogenic misfolding processes could be a unifying principle of general importance. A better understanding of this switching process, and the ability to design molecular systems which can be induced to switch between these conformations will have a significant impact on fields ranging from fundamental biochemistry through to applied technology and medicine.
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Cite this article as:
GroB Michael, Proteins that Convert from a Helix to b Sheet Implications for Folding and Disease, Current Protein & Peptide Science 2000; 1 (4) . https://dx.doi.org/10.2174/1389203003381289
DOI https://dx.doi.org/10.2174/1389203003381289 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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