Abstract
The lectin from the seeds of Canavalia brasiliensis (Con Br) was tested for its renal effects using the isolated perfusion rat kidney method. Three different doses were examined (3,10 and 30 microgram / ml), which were compared with a control group. The control group was perfused with only Krebs-Henseleit solution containing 6 percent BSA. Con Br caused diuresis and natriuresis, with a mild alteration on the perfusion pressure. Probably the lectin is inhibiting the Na+ / K+ / 2Cl- transporter present in the thick ascending limb of the Henle´s loop.
Keywords: LECTIN, CANAVALIA, BRASILIENSIS, Diocleinae, Phaseolae, Con Br, Eicosanoids, Phaseolus vulgaris, Canavalia ensiformis
Protein & Peptide Letters
Title: Renal Effects Of The Lectin From Canavalia Brasiliensis Seeds
Volume: 8 Issue: 6
Author(s): Edson H. Teixeira, Alexandre Havt, Paulo S.F. Barbosa, Dalgimar B. Meneses, Manasses C. Fonteles, Helena S.A. Monteiro, Alexander H. Sampaio and Benildo S. Cavada
Affiliation:
Keywords: LECTIN, CANAVALIA, BRASILIENSIS, Diocleinae, Phaseolae, Con Br, Eicosanoids, Phaseolus vulgaris, Canavalia ensiformis
Abstract: The lectin from the seeds of Canavalia brasiliensis (Con Br) was tested for its renal effects using the isolated perfusion rat kidney method. Three different doses were examined (3,10 and 30 microgram / ml), which were compared with a control group. The control group was perfused with only Krebs-Henseleit solution containing 6 percent BSA. Con Br caused diuresis and natriuresis, with a mild alteration on the perfusion pressure. Probably the lectin is inhibiting the Na+ / K+ / 2Cl- transporter present in the thick ascending limb of the Henle´s loop.
Export Options
About this article
Cite this article as:
Teixeira H. Edson, Havt Alexandre, Barbosa S.F. Paulo, Meneses B. Dalgimar, Fonteles C. Manasses, Monteiro S.A. Helena, Sampaio H. Alexander and Cavada S. Benildo, Renal Effects Of The Lectin From Canavalia Brasiliensis Seeds, Protein & Peptide Letters 2001; 8 (6) . https://dx.doi.org/10.2174/0929866013409094
DOI https://dx.doi.org/10.2174/0929866013409094 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Etiology and Treatment of LADA: An Update
Current Diabetes Reviews Neuroprotective Properties of Erythropoietin in Cerebral Ischemia
Central Nervous System Agents in Medicinal Chemistry Designing Novel Therapies Against Sarcomas in the Era of Personalized Medicine and Economic Crisis
Current Pharmaceutical Design An Evolutionary Approach for Structure-based Design of Natural and Non-natural Peptidic Ligands
Combinatorial Chemistry & High Throughput Screening Epigenetic Basis of Individual Variability to Major Psychosis
Current Pharmacogenomics and Personalized Medicine Vitamin D Supplementation for Obesity: Potential Mechanisms of Action and an Update of Randomized Controlled Trials
Current Nutrition & Food Science Regulation of Drug Metabolism and Transporters
Current Drug Metabolism Effects of Obesity Induced by High-Fat Diet on the Pharmacokinetics of Atazanavir in Rats
Drug Metabolism Letters From CHD Susceptibility Genes to New Therapeutics
Current Pharmacogenomics Chronopharmaceutics: A Promising Drug Delivery Finding of the Last Two Decades
Recent Patents on Drug Delivery & Formulation Variability in Individual Responsiveness to Aspirin: Clinical Implications and Treatment
Cardiovascular & Hematological Disorders-Drug Targets Diabetic Neuropathy: Update on Pathophysiological Mechanism and the Possible Involvement of Glutamate Pathways
Current Diabetes Reviews Roles of Glycogen Synthase Kinase 3 in Alzheimer’s Disease
Current Alzheimer Research Indian Spices for Healthy Heart - An Overview
Current Cardiology Reviews Patents in Targets and Drugs for Insulin Resistance: Correlation with Inflammatory Mediators
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery The TOLL-like / Type-I Interferon Pathways as Emerging Therapeutic Targets for Autoimmune Diseases
Drug Design Reviews - Online (Discontinued) Vascular Remodelling and Angiogenesis in Asthma: Morphological Aspects and Pharmacological Modulation
Inflammation & Allergy - Drug Targets (Discontinued) Breast Cancer: Understanding Sensitivity and Resistance to Chemotherapy and Targeted Therapies to Aid in Personalised Medicine
Current Cancer Drug Targets Do Adenosine Receptors Offer New Therapeutic Options for Diabetic Nephropathy?
Current Vascular Pharmacology An Updated Review on the Role of Single Nucleotide Polymorphisms in COVID-19 Disease Severity: A Global Aspect
Current Pharmaceutical Biotechnology