An Efficient, Flexible-Model Program For The Analysis Of Differential Scanning Calorimetry Protein Denaturation Data

Author(s): Sasha B. Grek, John K. Davis, Michael Blaber.

Journal Name: Protein & Peptide Letters

Volume 8 , Issue 6 , 2001

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Although thermodynamic formalisms for protein denaturation have been established for some time, available software programs for deconvolution of DSC data exhibit various limitations. These include enforcing a constant deltaCp(T), linear heat capacity functions, and so on. We have developed a Windows based program that allows greater flexibility, speed and accuracy than previously available programs for the analysis of DSC data. One novel feature of the program is the inclusion of, and ability to refine, a concentration-dependent term.

Keywords: PROTEIN DENATURATION, differential scanning calorimetry (DSC), DSCFit

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Article Details

Year: 2001
Page: [429 - 436]
Pages: 8
DOI: 10.2174/0929866013409184
Price: $65

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