In Vitro Degradation Of beta-Amyloid[25-35] Peptide

Author(s): Krisztina Jost, Jozsef Varga, Botond Pence, Marta Zarandi.

Journal Name: Protein & Peptide Letters

Volume 8 , Issue 6 , 2001

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Abstract:

Some amyloid-derived peptides show their toxic effects only after a long “aging” period performed several days at pH 7.4 and 37 C for cluster formation. Our experiments show that long aging of beta-amyloid[25-35] under physiological conditions results in peptide bond cleavage between Asn27 and Lys28. Relatively short incubation time (24 hours) and absence of Ca2+ ions prevent peptide cleavage and results in good aggregation of beta-amyloids.

Keywords: AMYLOID PEPTIDE, Alzheimer disease

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2001
Page: [423 - 428]
Pages: 6
DOI: 10.2174/0929866013409076
Price: $58

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