Triazine Conjugates for Multiple Site-Specific Labeling of Peptides

Author(s): Jonathan A. Zerkowski, Douglas A. Schftner.

Journal Name: Protein & Peptide Letters

Volume 8 , Issue 2 , 2001

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Abstract:

Mono- and di-substituted triazines were appended to the side chain of lysine or ornithine, which was then used in the synthesis of peptides. In this way, environment-sensitive reporter groups can be included in a sequence-specific manner in a peptide. The triazine adducts are stable to standard conditions employed in peptide synthesis. Several model peptides showing the utility of these conjugates were prepared

Keywords: triazine, peptides, aminochlorotriszines, fluorophores, ornithine

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2001
Page: [123 - 129]
Pages: 7
DOI: 10.2174/0929866013409562
Price: $58

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