Secondary Structure of the Homologous Proteins, A A-Fetoprotein and Serum Albumin, from their Circular Dichroism and Infrared Spectra | BenthamScience

Secondary Structure of the Homologous Proteins, A A-Fetoprotein and Serum Albumin, from their Circular Dichroism and Infrared Spectra

Author(s): Keith A. Oberg, Vladimir N. Uversky.

Journal Name: Protein & Peptide Letters

Volume 8 , Issue 4 , 2001

Abstract:

Secondary structure composition of two homologous proteins, alpha-fetoprotein and serum albumin, has been compared using circular dichroism and Fourier-transform infrared spectroscopy. CD-only analysis gives an accurate a-helical content for SA, but underestimates the predicted value for AFP. In contrast, FTIR-only analysis underestimates the helical content of SA. However, analysis of hybrid IR-CD spectra gives more accurate values for secondary structure composition for both AFP and SA and shows that the secondary structures of these proteins are the same.

Keywords: Proteins Fetoprotein, Serum Albumin, Circular Dichroism, Human serum albumin (HSA)

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Article Details

VOLUME: 8
ISSUE: 4
Year: 2001
Page: [297 - 302]
Pages: 6
DOI: 10.2174/0929866013409391
Price: $58

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