Nuclear Magnetic Resonance as a Tool in Drug Discovery, Metabolism and Disposition

Author(s): Susan Sondej Pochapsky, Thomas C. Pochapsky.

Journal Name: Current Topics in Medicinal Chemistry

Volume 1 , Issue 5 , 2001

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Abstract:

Nuclear magnetic resonance techniques have become critically important in the design of new pharmaceuticals, the characterization of drug-receptor interactions and metabolite identification. Advances in solvent suppression, coherent and incoherent magnetization transfer pathway selection, isotope editing and filtering, and diffusion filtering have made it possible to examine the interactions between small molecules and proteins or nucleic acids in great detail. Multiple schemes for high-throughput lead compound identification, metabolite screening and drug disposition have been proposed and reduced to practice. In particular, the coupling of NMR with other analytical methods, especially HPLC, combine the structural and dynamic detail available from NMR methods with the resolution and sensitivity of other analytical techniques.

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Article Details

VOLUME: 1
ISSUE: 5
Year: 2001
Page: [427 - 441]
Pages: 15
DOI: 10.2174/1568026013394967
Price: $58

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