Isolation and Structural Characterization of a Peptide from the Venom of Scorpion with Toxicity Towards Invertebrates and Vertebrates

Author(s): Gerardo Corzo, Elba Villegas, Terumi Nakajima.

Journal Name: Protein & Peptide Letters

Volume 8 , Issue 5 , 2001

Abstract:

Using a methodology based on HPLC fractionation, mass spectrometry analysis, and microinjection guide-bioassays, a peptide with toxicity to both insects and mammals was isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus, and named LqhIV (after LqhII and LqhIII[1]). The primary sequence, circular dichroism spectrum and three-dimensional structure simulation of LqhIV indicate that it contains similar structure to that of the group of alpha scorpion toxins.

Keywords: Leiurus quinquestriatus hebraeus, Androctonus australis, Leiurus quinquestriatus quinquestriatus, Hebraeus, Quinquestriatus

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Article Details

VOLUME: 8
ISSUE: 5
Year: 2001
Page: [385 - 393]
Pages: 9
DOI: 10.2174/0929866013409256
Price: $58

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