Abstract
alpha2-Adrenergic receptor agonists are analgesic agents, and the alpha2-adrenergic agonist clonidine has been used in clinical studies for regional analgesia after intrathecal administration. We review here recent developments concerning the structure activity relationships of a new class of potent alpha2-adrenergic agonists and their use as analgesic agents. The effect of structure upon cardiovascular side effects is also monitored, such as the prolongation of the QT portion of the cardiac action potential.
Keywords: Adrenergic Receptor, Agonists as Analgesics, Imidazoles and Imidazolines, Adrenoceptor Agonists, Catecholamines, Oxazolines
Current Topics in Medicinal Chemistry
Title: Alpha2-Adrenergic Receptor Agonists as Analgesics
Volume: 1 Issue: 3
Author(s): Robert E. Boyd
Affiliation:
Keywords: Adrenergic Receptor, Agonists as Analgesics, Imidazoles and Imidazolines, Adrenoceptor Agonists, Catecholamines, Oxazolines
Abstract: alpha2-Adrenergic receptor agonists are analgesic agents, and the alpha2-adrenergic agonist clonidine has been used in clinical studies for regional analgesia after intrathecal administration. We review here recent developments concerning the structure activity relationships of a new class of potent alpha2-adrenergic agonists and their use as analgesic agents. The effect of structure upon cardiovascular side effects is also monitored, such as the prolongation of the QT portion of the cardiac action potential.
Export Options
About this article
Cite this article as:
Boyd E. Robert, Alpha2-Adrenergic Receptor Agonists as Analgesics, Current Topics in Medicinal Chemistry 2001; 1 (3) . https://dx.doi.org/10.2174/1568026013395182
DOI https://dx.doi.org/10.2174/1568026013395182 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Gut Microbiome
Inflammation & Allergy - Drug Targets (Discontinued) γ-Secretase-Regulated Signaling: Notch, APP, and Alzheimers Disease
Current Psychopharmacology Fabrication of Electrochemical Sensor for Epinine Determination Amplified with MgO/CNTs Nanocomposite and Ionic Liquid
Current Analytical Chemistry Is there any Additional Prognostic Value of Central Blood Pressure Wave Forms Beyond Peripheral Blood Pressure?
Current Pharmaceutical Design Impact of Cellular Senescence in Aging and Cancer
Current Pharmaceutical Design Effects of Peach (Prunus persica)-Derived Glucosylceramide on the Human Skin
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Regulation of Angiogenesis and Angiogenic Factors by Cardiovascular Medications
Current Pharmaceutical Design Extrapituitary Actions of GnRH Antagonists: Prospects for in vitro Fertilization Programs
Current Pharmaceutical Design Neuro-Hormonal Regulation of Immune and Metabolic Function
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Progress in Target Drug Molecules for Alzheimer's Disease
Current Topics in Medicinal Chemistry False Positives in the Early Stages of Drug Discovery
Current Medicinal Chemistry QSAR, Docking, and CoMFA Studies of GSK3 Inhibitors
Current Pharmaceutical Design Lipid-Activated Nuclear Receptors and Sepsis
Endocrine, Metabolic & Immune Disorders - Drug Targets Viral Infection and Obesity: Current Status and Future Prospective
Current Drug Metabolism Patents on Red Blood Cell Manufacturing In Vitro
Recent Patents on Regenerative Medicine Contextualizing Genetics for Regional Heart Failure Care
Current Cardiology Reviews Trends in the Exploration of Therapeutic Targets for the Treatment of Endocrine, Metabolic and Immune Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets Flavonoids and Anthranquinones as Xanthine Oxidase and Monoamine Oxidase Inhibitors: A New Approach Towards Inflammation and Oxidative Stress
Current Topics in Medicinal Chemistry COPD and Type 2 Diabetes
Current Respiratory Medicine Reviews The Physiology of Learning and Memory: Role of Peptides and Stress
Current Protein & Peptide Science