Mini-Reviews in Medicinal Chemistry


Structure-Metabolism Relationships Steric Effects and the Enzymatic Hydrolysis of Carboxylic Esters

Author(s): Peter Buchwald

Affiliation: IVAX Corp., 4400 Biscayne Blvd., Miami, Florida 33137

Keywords: Structure Metabolism Relationships, Steric Effects, Enzymatic Hydrolysis, noncongener esters, quantitative structure-metabolism relationships, esterase activity, enantioselectivity, liposomal phosphatidylcholine, pharmacokinetic studies, Multiple halosubstituted


After a brief review of a number of issues related to the enzymatic hydrolysis of carboxylic esters, such as interspecies variability, mechanism, stereospecificity, and activation energy, and after an overview of relevant aspects related to the quantitative modeling of steric effects, the results of a recently developed quantitative structure-metabolism relationship model are discussed. They were obtained for in vitro human blood enzymatic hydrolysis of noncongener esters by introduction of the inaccessible solid angle as a novel measure of steric hindrance.

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Article Details

Page: [101 - 111]
Pages: 11
DOI: 10.2174/1389557013407403