Abstract
The knowledge of virus reproduction is necessary to design new safe drugs for inhibition of infections. Ultra-violet irradiation of virus proteins with labeled virus genome fragments permits to identify specific nucleic acid binding proteins. Affinity modification of enzymes with nucleotide derivatives could help to determine NTP-binding proteins and those involved in viral genome replication. Photoreactive analogues of nucleic acids are among the tools used to detect elongation subunits of replicative complexes. Affinity modification approach has already resulted in successful treatment of virus diseases.
Keywords: Viral Genomes, Proteins, Infuenza Virus trasnscriptase, Hiv reverse transcriptase, Avian myeloblastosis
Mini-Reviews in Medicinal Chemistry
Title: Viral Protein Functions Study by Affinity Modification
Volume: 1 Issue: 3
Author(s): O. V. Morozova and I. V. Safronov
Affiliation:
Keywords: Viral Genomes, Proteins, Infuenza Virus trasnscriptase, Hiv reverse transcriptase, Avian myeloblastosis
Abstract: The knowledge of virus reproduction is necessary to design new safe drugs for inhibition of infections. Ultra-violet irradiation of virus proteins with labeled virus genome fragments permits to identify specific nucleic acid binding proteins. Affinity modification of enzymes with nucleotide derivatives could help to determine NTP-binding proteins and those involved in viral genome replication. Photoreactive analogues of nucleic acids are among the tools used to detect elongation subunits of replicative complexes. Affinity modification approach has already resulted in successful treatment of virus diseases.
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Cite this article as:
Morozova V. O. and Safronov V. I., Viral Protein Functions Study by Affinity Modification, Mini-Reviews in Medicinal Chemistry 2001; 1 (3) . https://dx.doi.org/10.2174/1389557013406945
DOI https://dx.doi.org/10.2174/1389557013406945 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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