N-Oxides as Hypoxia Selective Cytotoxins

Author(s): Hugo Cerecetto, Mercedes Gonzalez.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 1 , Issue 3 , 2001

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Abstract:

N-Oxide-containing compounds have been developed as prodrugs that are selectively bioactivated in the hypoxic cells in tumors. This selectivity is based on the net reduction of the N-oxide moiety in the absence of oxygen, in a one or two-electron process, by reductive enzymes. A wide range of N-oxides have been studied and some of them are currently in clinical use. This review covers the principal families of compounds under study and in clinical trials.

Keywords: N-Oxides, Hypoxia, Cytotoxins, Tumor Hypoxia, Bioreductive Agents, Imidazopyridopyrazine N-Oxide and Imidazoquin-oxaline N-Oxide, Quinoxaline N,N-Dioxide, Aminoalkylaminoanthraquinone N-Oxide, Aminoalkylaminoacridine N-Oxide

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Article Details

VOLUME: 1
ISSUE: 3
Year: 2001
Page: [219 - 231]
Pages: 13
DOI: 10.2174/1389557013406891
Price: $58

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