Antibiotic Properties of Novel Synthetic Temporin A Analogs and a Cecropin A-Temporin A Hybrid Peptide

Author(s): David Wade, Jan-Ingmar Flock, Charlotta Edlund, Ingegerd Lofving-Arvholm, Matti Sallberg, Tomas Bergman, Angela Silveira, Cecille Unson, Louise Rollins-Smith, Jerzy Silberring, Malcom Richardson, Pentti Kuusela, Hilkka Lankinen.

Journal Name: Protein & Peptide Letters

Volume 9 , Issue 6 , 2002

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Abstract:

Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays.Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development.The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.

Keywords: temporin a, cecropin a, vescp-m, ranatuerin 6, antibiotic peptides, antibiotic resistant bacteria, antifungal, human erythrocyte lysis, hemolysis

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2002
Page: [533 - 543]
Pages: 11
DOI: 10.2174/0929866023408409
Price: $58

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