Mini-Reviews in Medicinal Chemistry

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Protection Against Cancer by Plant Phenylpropenoids: Induction of Mammalian Anticarcinogenic Enzymes

Author(s): A. T. Dinkova-Kostova

Affiliation: Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA

Abstract:

Chemoprotection has established itself as a “major arm” in the “war against cancer” and induction of phase 2 detoxification enzymes as an effective strategy. Prominent among inducers are Michael reaction acceptors. Such functionalities are intrinsic to many phenylpropanoids present in edible plants, where they play roles in plant defense. This minireview focuses on the ability of such plant metabolites to elevate phase 2 enzymes in various cell culture and animal models and ultimately to protect against carcinogenesis.

Keywords: plant phenylpropenoids, mammalian anticarcinogenic enzymes, chemoprotection, edible plants, carcinogenesis, double michael reaction acceptor

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Article Details

VOLUME: 2
ISSUE: 6
Page: [595 - 610]
Pages: 16
DOI: 10.2174/1389557023405558
Price: $58